Differential Modulation of Akt/Glycogen Synthase Kinase-3β Pathway Regulates Apoptotic and Cytoprotective Signaling Responses

We have previously reported that specific dopamine agonists mediate protection against apoptosis induced by oxidative stress by activating the D(2) receptor-coupled phosphoinositide 3-kinase (PI-3K)/Akt pathway. In the present study we examined the downstream effectors of PI-3K/Akt signaling and the...

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Bibliographic Details
Main Authors: Nair, Venugopalan D., Olanow, C. Warren
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258902/
https://ncbi.nlm.nih.gov/pubmed/18387957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707238200
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