Structural and Biophysical Characterization of Human myo-Inositol Oxygenase

Altered inositol metabolism is implicated in a number of diabetic complications. The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to d-glucuronate. Here, we...

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Main Authors: Thorsell, Ann-Gerd, Persson, Camilla, Voevodskaya, Nina, Busam, Robert D., Hammarström, Martin, Gräslund, Susanne, Gräslund, Astrid, Hallberg, B. Martin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Enzyme Catalysis and Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258897/
https://ncbi.nlm.nih.gov/pubmed/18364358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800348200
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