Interaction with the 5D3 Monoclonal Antibody Is Regulated by Intramolecular Rearrangements but Not by Covalent Dimer Formation of the Human ABCG2 Multidrug Transporter

Human ABCG2 is a plasma membrane glycoprotein working as a homodimer or homo-oligomer. The protein plays an important role in the protection/detoxification of various tissues and may also be responsible for the multidrug-resistant phenotype of cancer cells. In our previous study we found that the 5D...

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Main Authors: Özvegy-Laczka, Csilla, Laczkó, Rozália, Hegedűs, Csilla, Litman, Thomas, Várady, György, Goda, Katalin, Hegedűs, Tamás, Dokholyan, Nikolay V., Sorrentino, Brian P., Váradi, András, Sarkadi, Balázs
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Membrane Transport, Structure, Function, and Biogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258862/
https://ncbi.nlm.nih.gov/pubmed/18644784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803230200
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