High-resolution dose–response screening using droplet-based microfluidics

A critical early step in drug discovery is the screening of a chemical library. Typically, promising compounds are identified in a primary screen and then more fully characterized in a dose–response analysis with 7–10 data points per compound. Here, we describe a robust microfluidic approach that in...

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Autori principali: Miller, Oliver J., Harrak, Abdeslam El, Mangeat, Thomas, Baret, Jean-Christophe, Frenz, Lucas, Debs, Bachir El, Mayot, Estelle, Samuels, Michael L., Rooney, Eamonn K., Dieu, Pierre, Galvan, Martin, Link, Darren R., Griffiths, Andrew D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Physical Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258639/
https://ncbi.nlm.nih.gov/pubmed/22203966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113324109
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