Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain

Diverse mutations in the genes encoding hemoglobin (Hb) have been characterized in human disease. We describe here a mutation in the mouse Hbb-b2 gene, denoted Plt12, that precisely mimics the human hemoglobin Hotel Dieu variant. The mutation results in increased affinity of Hb for oxygen and Plt12...

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Bibliografiset tiedot
Päätekijät: Kauppi, Maria, Hilton, Adrienne A., Metcalf, Donald, Ng, Ashley P., Hyland, Craig D., Collinge, Janelle E., Kile, Benjamin T., Hilton, Douglas J., Alexander, Warren S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2012
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258592/
https://ncbi.nlm.nih.gov/pubmed/22203977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119146109
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