Effects of a novel DNA methyltransferase inhibitor Zebularine on human lens epithelial cells

PURPOSE: Posterior capsular opacification (PCO) is a common long-term complication of modern cataract surgery. We have shown that Zebularine, an inhibitor of DNA methylation, suppresses transforming growth factor-β (TGFβ)-induced lens epithelial cells (LECs)–myofibroblasts transdifferentiation. The...

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Hlavní autoři: Zhou, Peng, Lu, Yi, Sun, Xing-Huai
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258523/
https://ncbi.nlm.nih.gov/pubmed/22259221
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