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Mutant ubiquitin found in Alzheimer’s disease causes neuritic beading of mitochondria in association with neuronal degeneration
A dinucleotide deletion in human ubiquitin (Ub) B messenger RNA leads to formation of polyubiquitin (UbB) + 1, which has been implicated in neuronal cell death in Alzheimer’s and other neurodegenerative diseases. Previous studies demonstrate that UbB + 1 protein causes proteasome dysfunction. Howeve...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258508/ https://ncbi.nlm.nih.gov/pubmed/17571083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.cdd.4402180 |
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