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Role of Tumor Suppressor P53 in Megakaryopoiesis and Platelet Function

The pathobiological role of p53 has been widely studied, however its role in normophysiology is relatively unexplored. We previously showed that p53 knock-down increased ploidy in megakaryocytic cultures. This study aims to examine the effect of p53 loss on in vivo megakaryopoiesis, platelet product...

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Main Authors: Apostolidis, Pani A., Woulfe, Donna S., Chavez, Massiel, Miller, William M., Papoutsakis, Eleftherios T.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258354/
https://ncbi.nlm.nih.gov/pubmed/22024107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.10.006
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