TLR agonists and/or IL-15 adjuvanted mucosal SIV-vaccine reduced gut CD4(+) memory T cell loss in SIVmac251-challenged rhesus macaques

Adjuvant plays an important role in increasing and directing vaccine-induced immune responses. In a previous study, we found that a mucosal SIV vaccine using a combination of IL-15 and TLR agonists as adjuvant mediated partial protection against SIVmac251 rectal challenge, whereas neither IL-15 nor...

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Hauptverfasser: Sui, Yongjun, Gagnon, Susan, Dzutsev, Amiran, Zhu, Qing, Yu, Huifeng, Hogg, Alison, Wang, Yichuan, Xia, Zheng, Belyakov, Igor M., Venzon, David, Klinman, Dennis, Strober, Warren, Kelsall, Brian, Franchini, Genoveffa, Berzofsky, Jay A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258186/
https://ncbi.nlm.nih.gov/pubmed/22041305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.10.043
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