Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

Antigen recognition within immunological synapses triggers and sustains T cell activation by nucleating protein microclusters that gather T cell receptors (TCRs), kinases, and adaptors. Dissipation of these microclusters results in signal termination, but how this process is regulated is unclear. In...

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Hlavní autoři: Lasserre, Rémi, Cuche, Céline, Blecher-Gonen, Ronnie, Libman, Evgeny, Biquand, Elise, Danckaert, Anne, Yablonski, Deborah, Alcover, Andrés, Di Bartolo, Vincenzo
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2011
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257567/
https://ncbi.nlm.nih.gov/pubmed/22105350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201103105
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