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When more is less: Excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease

The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely af...

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Bibliografiske detaljer
Main Authors: Raben, Nina, Baum, Rebecca, Schreiner, Cynthia, Takikita, Shoichi, Mizushima, Noboru, Ralston, Evelyn, Plotz, Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257549/
https://ncbi.nlm.nih.gov/pubmed/19001870
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