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Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, the genetic deficiency of the glycogen-degrading lysosomal enzyme acid-alpha glucosidase. Accumulation of lysosomal glycogen, presumably transported from th...

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Main Authors: Raben, Nina, Hill, Victoria, Shea, Lauren, Takikita, Shoichi, Baum, Rebecca, Mizushima, Noboru, Ralston, Evelyn, Plotz, Paul
格式: Artigo
語言:Inglês
出版: Oxford University Press 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638578/
https://ncbi.nlm.nih.gov/pubmed/18782848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn292
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