Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77

Dysregulation of β-catenin turnover due to mutations of its regulatory proteins including APC and p53 is implicated in the pathogenesis of cancer. Thus, intensive effort is being made to search for alternative approaches to reduce abnormally activated β-catenin in cancer cells. Nur77, an orphan memb...

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Huvudupphovsmän: Sun, Zhe, Cao, Xihua, Jiang, Miao-Miao, Qiu, Yingkun, Zhou, Hu, Chen, Liqun, Qin, Bin, Wu, Hua, Jiang, Fuquan, Chen, Jiebo, Liu, Jie, Dai, Yi, Chen, Hai-Feng, Hu, Qiong-ying, Wu, Zhen, Zeng, Jin-zhang, Yao, Xin-Sheng, Zhang, Xiao-kun
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257393/
https://ncbi.nlm.nih.gov/pubmed/21986938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.448
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