Dynamic Ligand Modulation of EPO Receptor Pools, and Dysregulation by Polycythemia-Associated EPOR Alleles

Erythropoietin (EPO) and its cell surface receptor (EPOR) are essential for erythropoiesis; can modulate non-erythroid target tissues; and have been reported to affect the progression of certain cancers. Basic studies of EPOR expression and trafficking, however, have been hindered by low-level EPOR...

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Bibliographic Details
Main Authors: Singh, Seema, Verma, Rakesh, Pradeep, Anamika, Leu, Karen, Mortensen, R. Bruce, Young, Peter R., Oyasu, Miho, Schatz, Peter J., Green, Jennifer M., Wojchowski, Don M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257245/
https://ncbi.nlm.nih.gov/pubmed/22253704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029064
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