A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune...

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Détails bibliographiques
Auteurs principaux: Guerini, Franca Rosa, Cagliani, Rachele, Forni, Diego, Agliardi, Cristina, Caputo, Domenico, Cassinotti, Andrea, Galimberti, Daniela, Fenoglio, Chiara, Biasin, Mara, Asselta, Rosanna, Scarpini, Elio, Comi, Giacomo P., Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257233/
https://ncbi.nlm.nih.gov/pubmed/22253828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029931
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