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Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

P-glycoprotein (Pgp), a member of the ATP-binding cassette transporter family, functions as an ATP hydrolysis-driven efflux pump to rid the cell of toxic organic compounds, including a variety of drugs used in anticancer chemotherapy. Here, we used fluorescence resonance energy transfer (FRET) spect...

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Détails bibliographiques
Auteurs principaux: Verhalen, Brandy, Ernst, Stefan, Börsch, Michael, Wilkens, Stephan
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256922/
https://ncbi.nlm.nih.gov/pubmed/22086917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301192
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