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STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons

The neuroprotective actions of PACAP (pituitary adenylate cyclase-activating polypeptide) in vitro and in vivo suggest that activation of its cognate G protein-coupled receptor PAC1 or downstream signaling molecules, and thus activation of PACAP target genes, could be of therapeutic benefit. Here we...

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Autores principales: Holighaus, Yvonne, Weihe, Eberhard, Eiden, Lee E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256285/
https://ncbi.nlm.nih.gov/pubmed/21975601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-011-9653-9
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