Mitochondrial Electron Transport Is the Cellular Target of the Oncology Drug Elesclomol

Elesclomol is a first-in-class investigational drug currently undergoing clinical evaluation as a novel cancer therapeutic. The potent antitumor activity of the compound results from the elevation of reactive oxygen species (ROS) and oxidative stress to levels incompatible with cellular survival. Ho...

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Détails bibliographiques
Auteurs principaux: Blackman, Ronald K., Cheung-Ong, Kahlin, Gebbia, Marinella, Proia, David A., He, Suqin, Kepros, Jane, Jonneaux, Aurelie, Marchetti, Philippe, Kluza, Jerome, Rao, Patricia E., Wada, Yumiko, Giaever, Guri, Nislow, Corey
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256171/
https://ncbi.nlm.nih.gov/pubmed/22253786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029798
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