Downregulation of Mitogen-Activated Protein Kinase 1 of Leishmania donovani Field Isolates Is Associated with Antimony Resistance

Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) on the Indian subcontinent. The mechanisms operating in laboratory-generated strains are somewhat known, but the determinants of clinical antimony resistance are not well u...

Full description

Saved in:
Bibliographic Details
Main Authors: Ashutosh, Garg, Mansi, Sundar, Shyam, Duncan, Robert, Nakhasi, Hira L., Goyal, Neena
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256019/
https://ncbi.nlm.nih.gov/pubmed/22064540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00736-11
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items