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Optimized Adenovirus-Antibody Complexes Stimulate Strong Cellular and Humoral Immune Responses against an Encoded Antigen in Naïve Mice and Those with Preexisting Immunity

The immune response to recombinant adenoviruses is the most significant impediment to their clinical use for immunization. We test the hypothesis that specific virus-antibody combinations dictate the type of immune response generated against the adenovirus and its transgene cassette under certain ph...

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Detalhes bibliográficos
Main Authors: Choi, Jin Huk, Dekker, Joe, Schafer, Stephen C., John, Jobby, Whitfill, Craig E., Petty, Christopher S., Haddad, Eid E., Croyle, Maria A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255947/
https://ncbi.nlm.nih.gov/pubmed/22089246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05319-11
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