Epstein-Barr Virus Isolates Retain Their Capacity To Evade T Cell Immunity through BNLF2a despite Extensive Sequence Variation

The Epstein-Barr virus (EBV)-encoded immune evasion protein BNLF2a inhibits the transporter associated with antigen processing (TAP), thereby downregulating HLA class I expression at the cell surface. As a consequence, recognition of EBV-infected cells by cytotoxic T cells is impaired. Here, we show...

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Detaylı Bibliyografya
Asıl Yazarlar: Horst, Daniëlle, Burrows, Scott R., Gatherer, Derek, van Wilgenburg, Bonnie, Bell, Melissa J., Boer, Ingrid G. J., Ressing, Maaike E., Wiertz, Emmanuel J. H. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Pathogenesis and Immunity
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255881/
https://ncbi.nlm.nih.gov/pubmed/22013037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05151-11
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