Combination of PB2 271A and SR Polymorphism at Positions 590/591 Is Critical for Viral Replication and Virulence of Swine Influenza Virus in Cultured Cells and In Vivo

Triple reassortant swine influenza viruses (SIVs) and 2009 pandemic H1N1 (pH1N1) virus contain an avian-origin PB2 with 271A, 590S, 591R, and 627E. To evaluate the role of PB2 271A, 590S, and 591R in the replication and virulence of SIV, single (1930-TX98-PB2-271T)-, double (1930-TX98-PB2-590A591A)-...

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Bibliographic Details
Main Authors: Liu, Qinfang, Qiao, Chuanling, Marjuki, Henju, Bawa, Bhupinder, Ma, Jingqun, Guillossou, Stephane, Webby, Richard J., Richt, Jürgen A., Ma, Wenjun
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255826/
https://ncbi.nlm.nih.gov/pubmed/22072752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05699-11
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