Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models

PB2 627K is a determinant of influenza host range and contributes to the pathogenicity of human-, avian-, and mouse-adapted influenza viruses in the mouse model. Here we used mouse and pig models to analyze the contribution of a swine-origin and avian-origin PB2 carrying either 627K or 627E in the b...

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Detalhes bibliográficos
Main Authors: Ma, Wenjun, Lager, Kelly M., Li, Xi, Janke, Bruce H., Mosier, Derek A, Painter, Laura E., Ulery, Eva S., Ma, Jingqun, Lekcharoensuk, Porntippa, Webby, Richard J., Richt, Jürgen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033585/
https://ncbi.nlm.nih.gov/pubmed/21074235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.10.027
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