Viral Adaptation to Host Immune Responses Occurs in Chronic Hepatitis B Virus (HBV) Infection, and Adaptation Is Greatest in HBV e Antigen-Negative Disease

Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to identify novel HBV T-cell epitopes by examini...

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Main Authors: Desmond, Christopher P., Gaudieri, Silvana, James, Ian R., Pfafferott, Katja, Chopra, Abha, Lau, George K., Audsley, Jennifer, Day, Caroline, Chivers, Sarah, Gordon, Adam, Revill, Peter A., Bowden, Scott, Ayres, Anna, Desmond, Paul V., Thompson, Alexander J., Roberts, Stuart K., Locarnini, Stephen A., Mallal, Simon A., Lewin, Sharon R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255822/
https://ncbi.nlm.nih.gov/pubmed/22072755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05308-11
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