Viral Adaptation to Host Immune Responses Occurs in Chronic Hepatitis B Virus (HBV) Infection, and Adaptation Is Greatest in HBV e Antigen-Negative Disease

Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to identify novel HBV T-cell epitopes by examini...

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Main Authors: Desmond, Christopher P., Gaudieri, Silvana, James, Ian R., Pfafferott, Katja, Chopra, Abha, Lau, George K., Audsley, Jennifer, Day, Caroline, Chivers, Sarah, Gordon, Adam, Revill, Peter A., Bowden, Scott, Ayres, Anna, Desmond, Paul V., Thompson, Alexander J., Roberts, Stuart K., Locarnini, Stephen A., Mallal, Simon A., Lewin, Sharon R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255822/
https://ncbi.nlm.nih.gov/pubmed/22072755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05308-11
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