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Evidence against Extracellular Exposure of a Highly Immunogenic Region in the C-Terminal Domain of the Simian Immunodeficiency Virus gp41 Transmembrane Protein

The generally accepted model for human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein topology includes a single membrane-spanning domain. An alternate model has been proposed which features multiple membrane-spanning domains. Consistent with the alternate model, a high percentage of HI...

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Main Authors: Postler, Thomas S., Martinez-Navio, José M., Yuste, Eloísa, Desrosiers, Ronald C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255797/
https://ncbi.nlm.nih.gov/pubmed/22072749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06463-11
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