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Frat Is a Phosphatidylinositol 3-Kinase/Akt-Regulated Determinant of Glycogen Synthase Kinase 3β Subcellular Localization in Pluripotent Cells

Suppressing the activity of Gsk3β is critical for maintenance of murine pluripotent stem cells. In murine embryonic stem cells (mESCs), Gsk3β is inhibited by multiple mechanisms, including its inhibitory phosphorylation on serine 9 by protein kinase B (Akt), a major effector of the canonical phospha...

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Bibliografski detalji
Glavni autori: Bechard, Matthew, Trost, Robert, Singh, Amar M., Dalton, Stephen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255773/
https://ncbi.nlm.nih.gov/pubmed/22064483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05372-11
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