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Localization of HET-S to the Cell Periphery, Not to [Het-s] Aggregates, Is Associated with [Het-s]–HET-S Toxicity

Prion diseases are associated with accumulation of the amyloid form of the prion protein, but the mechanisms of toxicity are unknown. Amyloid toxicity is also associated with fungal prions. In Podospora anserina, the simultaneous presence of [Het-s] prion and its allelic protein HET-S causes cell de...

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Detalhes bibliográficos
Main Authors: Mathur, Vidhu, Seuring, Carolin, Riek, Roland, Saupe, Sven J., Liebman, Susan W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255711/
https://ncbi.nlm.nih.gov/pubmed/22037764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06125-11
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