RrgB321, a Fusion Protein of the Three Variants of the Pneumococcal Pilus Backbone RrgB, Is Protective In Vivo and Elicits Opsonic Antibodies

Streptococcus pneumoniae pilus 1 is present in 30 to 50% of invasive disease-causing strains and is composed of three subunits: the adhesin RrgA, the major backbone subunit RrgB, and the minor ancillary protein RrgC. RrgB exists in three distinct genetic variants and, when used to immunize mice, ind...

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Main Authors: Harfouche, Carole, Filippini, Sara, Gianfaldoni, Claudia, Ruggiero, Paolo, Moschioni, Monica, Maccari, Silvia, Pancotto, Laura, Arcidiacono, Letizia, Galletti, Bruno, Censini, Stefano, Mori, Elena, Giuliani, Marzia, Facciotti, Claudia, Cartocci, Elena, Savino, Silvana, Doro, Francesco, Pallaoro, Michele, Nocadello, Salvatore, Mancuso, Giuseppe, Haston, Mitch, Goldblatt, David, Barocchi, Michèle A., Pizza, Mariagrazia, Rappuoli, Rino, Masignani, Vega
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255673/
https://ncbi.nlm.nih.gov/pubmed/22083702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05780-11
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