Role of Toll Interleukin-1 Receptor (IL-1R) 8, a Negative Regulator of IL-1R/Toll-Like Receptor Signaling, in Resistance to Acute Pseudomonas aeruginosa Lung Infection

Toll interleukin-1 receptor (IL-1R) 8 (TIR8), also known as single Ig IL-1 receptor (IL-R)-related molecule, or SIGIRR, is a member of the IL-1R-like family, primarily expressed by epithelial cells. Current evidence suggests that TIR8 plays a nonredundant role as a negative regulator in vivo under d...

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Hauptverfasser: Véliz Rodriguez, Tania, Moalli, Federica, Polentarutti, Nadia, Paroni, Moira, Bonavita, Eduardo, Anselmo, Achille, Nebuloni, Manuela, Mantero, Stefano, Jaillon, Sébastien, Bragonzi, Alessandra, Mantovani, Alberto, Riva, Federica, Garlanda, Cecilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255652/
https://ncbi.nlm.nih.gov/pubmed/22025515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05695-11
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