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When Second Best Is Good Enough: Another Probabilistic Look at Saturation Mutagenesis
We developed new criteria for determining the library size in a saturation mutagenesis experiment. When the number of all possible distinct variants is large, any of the top-performing variants (e.g., any of the top three) is likely to meet the design requirements, so the probability that the librar...
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology
2012
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255629/ https://ncbi.nlm.nih.gov/pubmed/22038607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.06265-11 |
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