Verapamil Results in Increased Blood Levels of Oncolytic Adenovirus in Treatment of Patients With Advanced Cancer

Calcium channel blockers including verapamil have been proposed to enhance release and antitumor efficacy of oncolytic adenoviruses in preclinical studies but this has not been studied in humans before. Here, we studied if verapamil leads to increased replication of oncolytic adenovirus in cancer pa...

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Main Authors: Koski, Anniina, Raki, Mari, Nokisalmi, Petri, Liikanen, Ilkka, Kangasniemi, Lotta, Joensuu, Timo, Kanerva, Anna, Pesonen, Sari, Alemany, Ramon, Hemminki, Akseli
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255582/
https://ncbi.nlm.nih.gov/pubmed/22044933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.230
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