Delivery of siRNA to the Mouse Lung via a Functionalized Lipopolyamine

We have designed a series of versatile lipopolyamines which are amenable to chemical modification for in vivo delivery of small interfering RNA (siRNA). This report focuses on one such lipopolyamine (Staramine), its functionalized derivatives and the lipid nanocomplexes it forms with siRNA. Intraven...

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Detalhes bibliográficos
Main Authors: Polach, Kevin J, Matar, Majed, Rice, Jennifer, Slobodkin, Gregory, Sparks, Jeff, Congo, Richard, Rea-Ramsey, Angela, McClure, Diane, Brunhoeber, Elaine, Krampert, Monika, Schuster, Andrea, Jahn-Hofmann, Kerstin, John, Matthias, Vornlocher, Hans-Peter, Fewell, Jason G, Anwer, Khursheed, Geick, Anke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255578/
https://ncbi.nlm.nih.gov/pubmed/21988874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.210
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