Myeloma cells suppress osteoblasts through sclerostin secretion

Wingless-type (Wnt) signaling through the secretion of Wnt inhibitors Dickkopf1, soluble frizzled-related protein-2 and -3 has a key role in the decreased osteoblast (OB) activity associated with multiple myeloma (MM) bone disease. We provide evidence that another Wnt antagonist, sclerostin, an oste...

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Detalhes bibliográficos
Main Authors: Colucci, S, Brunetti, G, Oranger, A, Mori, G, Sardone, F, Specchia, G, Rinaldi, E, Curci, P, Liso, V, Passeri, G, Zallone, A, Rizzi, R, Grano, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255263/
https://ncbi.nlm.nih.gov/pubmed/22829171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.22
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