LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

LIGHT, a TNF superfamily member, is involved in T-cell homeostasis and erosive bone disease associated with rheumatoid arthritis. Herein, we investigated whether LIGHT has a role in Multiple Myeloma (MM)-bone disease. We found that LIGHT was overproduced by CD14+ monocytes, CD8+ T-cells and neutroph...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Brunetti, Giacomina, Rizzi, Rita, Oranger, Angela, Gigante, Isabella, Mori, Giorgio, Taurino, Grazia, Mongelli, Teresa, Colaianni, Graziana, Di Benedetto, Adriana, Tamma, Roberto, Ingravallo, Giuseppe, Napoli, Anna, Faienza, Maria Felicia, Mestice, Anna, Curci, Paola, Specchia, Giorgina, Colucci, Silvia, Grano, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350341/
https://ncbi.nlm.nih.gov/pubmed/25460501
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