Gene expression signatures associated with the in vitro resistance to two tyrosine kinase inhibitors, nilotinib and imatinib

The use of selective inhibitors targeting Bcr-Abl kinase is now established as a standard protocol in the treatment of chronic myelogenous leukemia; however, the acquisition of drug resistance is a major obstacle limiting the treatment efficacy. To elucidate the molecular mechanism of drug resistanc...

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Главные авторы: Kim, T-M, Ha, S-A, Kim, H K, Yoo, J, Kim, S, Yim, S-H, Jung, S-H, Kim, D-W, Chung, Y-J, Kim, J W
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2011
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255246/
https://ncbi.nlm.nih.gov/pubmed/22829191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.32
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