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Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis

The transcriptional regulator DosR from M. tuberculosis plays a crucial role in the virulence to dormancy transition of the pathogen. DosR can be activated by DosT and DosS, two histidine kinases with heme-containing sensor GAF domains, capable of diatomic ligand binding, To investigate the initial...

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Detalhes bibliográficos
Main Authors: Vos, Marten H., Bouzhir-Sima, Latifa, Lambry, Jean-Christophe, Luo, Hao, Eaton-Rye, Julian J., Ioanoviciu, Alexandra, Ortiz de Montellano, Paul R., Liebl, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254832/
https://ncbi.nlm.nih.gov/pubmed/22142262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201467c
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