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Metabolism as a key to histone deacetylase inhibition

There is growing interest in the epigenetic mechanisms that are dysregulated in cancer and other human pathologies. Under this broad umbrella, modulators of histone deacetylase (HDAC) activity have gained interest as both cancer chemopreventive and therapeutic agents. Of the first generation, FDA-ap...

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Main Authors: Rajendran, Praveen, Williams, David E., Ho, Emily, Dashwood, Roderick H.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254183/
https://ncbi.nlm.nih.gov/pubmed/21599534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2011.557713
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