Transient transfection of serum-free suspension HEK 293 cell culture for efficient production of human rFVIII

BACKGROUND: Hemophilia A is a bleeding disorder caused by deficiency in coagulation factor VIII. Recombinant factor VIII (rFVIII) is an alternative to plasma-derived FVIII for the treatment of hemophilia A. However, commercial manufacturing of rFVIII products is inefficient and costly and is associa...

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Main Authors: Swiech, Kamilla, Kamen, Amine, Ansorge, Sven, Durocher, Yves, Picanço-Castro, Virgínia, Russo-Carbolante, Elisa MS, Neto, Mário SA, Covas, Dimas T
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254136/
https://ncbi.nlm.nih.gov/pubmed/22115125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-11-114
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