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The DNA Replication Stress Hypothesis of Alzheimer's Disease

A well-recognized theory of Alzheimer's disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. Chromosome reduplicati...

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Détails bibliographiques
Auteurs principaux: Yurov, Yuri B., Vorsanova, Svetlana G., Iourov, Ivan Y.
Format: Artigo
Langue:Inglês
Publié: TheScientificWorldJOURNAL 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254013/
https://ncbi.nlm.nih.gov/pubmed/22262948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1100/2011/625690
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