GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny

Genomic instability (GIN) and chromosome instability (CIN) are two closely related ways to produce a variety of pathogenic conditions, i.e. cancer, neurodegeneration, chromosomal and genomic diseases. The GIN and CIN manifestation that possesses the most appreciable impact on cell physiology and via...

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Bibliographic Details
Main Authors: Yurov, Yuri B, Vorsanova, Svetlana G, Iourov, Ivan Y
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Hypothesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787505/
https://ncbi.nlm.nih.gov/pubmed/19939257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8166-2-23
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