2-(3,4-dihydro-2H-pyrrolium-1-yl)-3oxoindan-1-olate (DHPO), a Novel, Synthetic Small Molecule that Alleviates Insulin Resistance and Lipid Abnormalities

Type-2 diabetes is growing at epidemic proportions world-wide. This report describes the effect of a novel, synthetic, small molecule 2-(3, 4-dihydro-2H-pyrrolium-1-yl)-3oxoindan-1-olate (DHPO), on metabolic abnormalities in genetic and dietary mouse models of type-2 diabetes. DHPO (20mg/kg/d i.p. f...

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Main Authors: Kandadi, Machender R., Rajanna, Prabhakar K., Unnikrishnan, Mazhuvancherry K., Boddu, Sai P., Hau, Yinan, Li, Ji, Du, Min, Ren, Jun, Sreejayan, Nair
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254000/
https://ncbi.nlm.nih.gov/pubmed/19769946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.09.018
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