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Engineering endomorphin drugs: state of the art
IMPORTANCE OF THE FIELD: Although EM-1 (H-Tyr-Pro-Phe-Trp-NH(2)) and EM-2 (H-Tyr-Pro-Phe-Phe-NH(2)) are primarily considered agonists for the μ-opioid receptor (MOR), systematic alterations to specific residues provided antagonists and ligands with mixed μ/δ-opioid properties suitable for applicatio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3253703/ https://ncbi.nlm.nih.gov/pubmed/22214283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543776.2012.646261 |
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