ANTIBODY MECHANICS ON A MEMBRANE-BOUND HIV SEGMENT ESSENTIAL FOR GP41-TARGETED VIRAL NEUTRALIZATION

Broadly neutralizing antibodies (BNAbs) such as 2F5 are directed against the HIV-1 GP41 membrane proximal external region (MPER) and recognize well-defined linear core sequences. These epitopes can be engrafted onto protein scaffolds, serving as immunogens with high structural fidelity. Although ant...

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Detalhes bibliográficos
Main Authors: Kim, Mikyung, Sun, Zhen-Yu J., Rand, Kasper D., Shi, Xiaomeng, Song, Likai, Cheng, Yuxing, Fahmy, Amr F., Majumdar, Shreoshi, Ofek, Gilad, Yang, Yongping, Kwong, Peter D., Wang, Jia-huai, Engen, John R., Wagner, Gerhard, Reinherz, Ellis L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253551/
https://ncbi.nlm.nih.gov/pubmed/22002224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2154
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