T cell receptor signaling is limited by docking geometry to peptide-Major Histocompatibility Complex

T cell receptor (TCR) engagement of peptide-major histocompatibility complex (MHC) is essential to adaptive immunity, but it is unknown if TCR signaling responses are influenced by the binding topology of the TCR-peptide-MHC complex. We developed yeast-displayed peptide-MHC libraries that enabled us...

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Detalhes bibliográficos
Main Authors: Adams, Jarrett J., Narayanan, Samanthi, Liu, Baoyu, Birnbaum, Michael E., Kruse, Andrew, Bowerman, Natalie A., Chen, Wei, Levin, Aron M., Connolly, Janet M., Zhu, Cheng, Kranz, David M., Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253265/
https://ncbi.nlm.nih.gov/pubmed/22101157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.09.013
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