T cell receptor signaling is limited by docking geometry to peptide-Major Histocompatibility Complex

T cell receptor (TCR) engagement of peptide-major histocompatibility complex (MHC) is essential to adaptive immunity, but it is unknown if TCR signaling responses are influenced by the binding topology of the TCR-peptide-MHC complex. We developed yeast-displayed peptide-MHC libraries that enabled us...

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Autors principals: Adams, Jarrett J., Narayanan, Samanthi, Liu, Baoyu, Birnbaum, Michael E., Kruse, Andrew, Bowerman, Natalie A., Chen, Wei, Levin, Aron M., Connolly, Janet M., Zhu, Cheng, Kranz, David M., Garcia, K. Christopher
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253265/
https://ncbi.nlm.nih.gov/pubmed/22101157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.09.013
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