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NEMO-LIKE KINASE INHIBITS OSTEOBLASTOGENESIS BY SUPPRESSING BONE MORPHOGENETIC PROTEIN AND WNT CANONICAL SIGNALING

The bone morphogenetic protein/Signaling mothers against decapentaplegic (BMP/Smad) and the WNT signaling pathways regulate the commitment of mesenchymal cells to the osteoblastic lineage. Nemo like kinase (Nlk) is an evolutionary conserved kinase that suppresses Smad transactivation and WNT canonic...

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Detalhes bibliográficos
Main Authors: Zanotti, Stefano, Canalis, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253257/
https://ncbi.nlm.nih.gov/pubmed/21928348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23365
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