Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

Cisplatin is a widely used anti-neoplastic agent; however, its major limitation is the development of dose-dependent nephrotoxicity whose precise mechanisms are poorly understood. Here we show that mitochondrial dysfunction is not only a feature of cisplatin nephrotoxicity, but that targeted deliver...

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Main Authors: Mukhopadhyay, Partha, Horváth, Béla, Zsengellér, Zsuzsanna, Zielonka, Jacek, Tanchian, Galin, Holovac, Eileen, Kechrid, Malek, Patel, Vivek, Stillman, Isaac E., Parikh, Samir M., Joseph, Joy, Kalyanaraman, Balaraman, Pacher, Pál
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253235/
https://ncbi.nlm.nih.gov/pubmed/22120494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.11.001
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