The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness (AHR) and Inflammation

Activation of the alternative pathway of complement plays a critical role in the development of allergen-induced airway hyperresponsiveness (AHR) and inflammation in mice. Endogenous factor H, a potent inhibitor of the alternative pathway, is increased in the airways of sensitized and challenged mic...

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Main Authors: Takeda, Katsuyuki, Thurman, Joshua M., Tomlinson, Stephen, Okamoto, Masakazu, Shiraishi, Yoshiki, Ferreira, Viviana P., Cortes, Claudio, Pangburn, Michael K., Holers, V. Michael, Gelfand, Erwin W.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253223/
https://ncbi.nlm.nih.gov/pubmed/22174452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101813
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