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Alpha synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases

Intracellular deposition of fibrillar aggregates of alpha synuclein (αSyn) characterizes neurodegenerative diseases such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, recent evidence indicates that small αSyn oligomeric aggregates that precede fibril formation may be the...

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Detalhes bibliográficos
Main Authors: Martin, Zane S., Neugebauer, Volker, Dineley, Kelly T., Kayed, Rakez, Zhang, Wenru, Reese, Lindsay C., Taglialatela, Giulio
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253169/
https://ncbi.nlm.nih.gov/pubmed/22060133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07576.x
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