Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression

Naturally SIV-infected sooty mangabeys (SMs) do not progress to AIDS despite high-level virus replication. We previously showed that the fraction of CD4+CCR5+ T-cells is lower in SMs compared to humans and macaques. Here we found that, after in vitro stimulation, SM CD4+ T-cells fail to up-regulate...

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Hauptverfasser: Paiardini, Mirko, Cervasi, Barbara, Reyes-Aviles, Elane, Micci, Luca, Ortiz, Alexandra M., Chahroudi, Ann, Vinton, Carol, Gordon, Shari N., Bosinger, Steven E., Francella, Nicholas, Hallberg, Paul L., Schlub, Timothy, Chan, Ming Liang, Riddick, Nadeene E., Collman, Ronald G., Apetrei, Cristian, Pandrea, Ivona, Else, James, Munch, Jan, Kirchhoff, Frank, Davenport, Miles P., Brenchley, Jason M., Silvestri, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253129/
https://ncbi.nlm.nih.gov/pubmed/21706028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2395
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