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Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery
Supercoiled DNAs varying from 281 to 5302 bp were subjected to shear forces generated by aerosolization or sonication. DNA shearing strongly correlated with length. Typical sized plasmids (⩾3000 bp) degraded rapidly. DNAs 2000–3000 bp persisted ∼10 min. Even in the absence of condensing agents, supe...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252587/ https://ncbi.nlm.nih.gov/pubmed/21633394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.77 |
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